STELARA® overview


What is STELARA® and how does it work?

STELARA® is a 'biologic' therapy for adults and children aged 12 years and older with moderate to severe plaque psoriasis, adults with active psoriatic arthritis and adults with moderate to severely active Crohn's disease.

The active substance is called a "monoclonal antibody". Monoclonal antibodies are proteins that recognise and bind to other specific proteins in the body. In this case, it works with your immune system to reduce inflammation and other signs of your psoriatic disease.

STELARA® works with your immune system to reduce inflammation and other signs of your disease. It targets and blocks the action of two cytokines (chemicals in the body) called IL-12 and IL-23.21 These cytokines are likely to be present in high levels and cause inflamed cells.

Stelara Mode of Action

If you have questions about STELARA®, go to FAQs for more information or see the Product Information Leaflet supplied with your medication. You can also talk to your doctor.

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Who is STELARA® for?

STELARA® is used to treat the following:

  • Moderate to severe plaque psoriasis in adults and children aged 12 years and older
  • Active psoriatic arthritis in adults
  • Active moderate to severely active Crohn's Disease in adults


What does STELARA® contain?

Each of the pre-filled syringes contains either 45mg or 90mg of ustekinumab. Alternatively a 45mg vial is available for children aged 12-18 years old who weigh <60kg and need to be administered a weight-based dose.
A 130 mg vial is available to initiate treatment in adults with Crohn's disease.


When to take your STELARA®?

To get the full benefit from your treatment, use it as directed by your doctor.

If you are being treated for Crohn's disease, your first dose is given in a hospital by a healthcare professional as a drip in a vein in your arm (intravenous infusion). After the starting intravenous dose you will have the next dose of 90mg by injection under your skin (subcutaneous injection) 8 weeks later, and then every 8 or 12 weeks thereafter.

If you have psoriasis and/or psoriatic arthritis, STELARA® is always given as as injection under the skin (subcutaneous injection):
- In adults and the elderly, the recommended dose is 45mg at week 0, week 4 and then every 12 weeks thereafter. For psoriasis patients the recommended dose is 90mg if you weigh more than 100kg. For psoriatic arthritis patients, if you weigh more than 100kg, a dose of either 45mg or 90mg may be given.
- In children aged 12 years or older, the recommended dose is 0.75mg/kg if they weigh less than 60kg, 45mg if they weigh from 60kg to 100kg, and 90mg if they weigh more than 100kg. Doses are administered at week 0, week 4 and every 12 weeks thereafter.


To get the full benefit from your treatment, use it as directed by your doctor.

It is possible for you to choose to receive your STELARA® injections either at hospital visits, via the Homecare Service (administered at your home by a trained nurse), or by self-injection. You can talk to your health care team so that you can work out together which option is best.

For more information on how to use STELARA®, click here.